臧奕

個人簡介

2001年畢業于復旦大學醫學院（原上海醫科大學），獲醫學學士學位。同年7月進入中國科學院上海藥物研究所國家新藥篩選中心工作。2003年-2008年，中國科學院上海藥物研究所研究生，獲博士學位。2008年-2010年，美國M.D.Anderson腫瘤研究中心博士后。2010年10月被中國科學院上海藥物研究所聘為副研究員，碩士研究生導師，2014年10月被聘為研究員。目前已在J Biol Chem, Adv Mater, Chem Sci, Chem Soc Rev, Chem Commun (Camb), Mol Cancer Res, J Clin Invest等國際期刊上發表論文48篇，其中第一作者文章4篇，共同通訊作者文章10篇，申請專利2項。作為課題負責人完成上海市自然科學基金、國家自然科學基金資助青年項目和國家自然科學基金面上項目各一項。正在主持國家科技重大新藥創制項目子任務, 一項國家自然科學基金面上項目，一項上海市科委國際合作項目及中科院“個性化藥物”先導專項子課題。作為主要技術骨干人員參與完成國家重大科學研究計劃發育與生殖專項項目、中國科學院戰略性先導科技“干細胞與再生醫學研究”專項等。

工作經歷

研究方向

1. 細胞識別和細胞命運調控化學生物學研究； 

2. 基于AMPK激酶家族信號調控網絡的基礎研究；

3. 纖維化疾病創新藥物發現及評價研究；  

4. 基于表觀遺傳新靶點的創新藥物發現及評價研究；

科研項目

科研成果

榮譽獲獎

代表論著

1. Li KB, Li N, Zang Y, Chen GR, Li J*, James TD, He XP*, Tian H, Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules Chem. Sci., 2016, 7, 6325  IF/5-IF: 9.144/9.155     cited: 0 

2. Ji DK, Zhang Y, Zang Y, Li J*, Chen GR, He XP*, Tian H Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet. Adv Mater. 2016 Aug 29. IF/5-IF:18.96/18.862     cited: 0 

3. Hu XL, Zang Y, Li J*, Chen GR, James TD, He XP*, Tian H, Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites. Chem Sci 2016,7, 4004-4008 

4. Deo C, Wang H , Bogliotti N, Zang Y*, Retailleau P, He XP*, Li J, Xie J* Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: Synthesis, characterization and cytotoxicity. Journal of Organometallic Chemistry, 2016, 820: 111-119. IF/5-IF: 2.336/2.09    cited: 0 

5. Cheng J, Liu M, Shao BH, Zhang S, Li J, Hu YZ, Li X*, Zang Y*, Development of a novel H2S and GSH detection cocktail for fluorescence imaging. RSC Advances, 2016, 6, 59882-59888 IF/5-IF: 3.289/3.485    cited: 1 

6. Ji DK#, Zhang Y#, Zang Y*, Liu W， Zhang XW, Li J*, Chen GR, James，TD， He XP* Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite. J. Mater. Chem. B, 2015,3, 9182-9185 IF/5-IF: 4.872    /4.879    cited: 12 

7. Dong L#, Zang Y#, Zhou D, He XP*, Chen GR, James TD, Li J* Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe. Chem Commun (Camb). 2015, 51:11852-5  IF/5-IF: 6.567/6.628    cited: 19 

8. He XP#, Zang Y, James TD, Li J* and Chen GR* (2015) Probing disease-related proteins with fluorogenic composite materials Chem Soc Rev 2015 Jul 7;44(13):4239-4 IF/5-IF: 34.09/36.63    cited: 44 

9. He XP*，Zhu BW，Zang Y，Li J*, Chen GR, Tian H, Long YT* , Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl  glycoanthraquinone-decorated grapheme electrodes. Chem. Sci., 2015, 6, 1996 IF/5-IF: 9.144        /9.155    cited: 21 

10. Zhang L#, Wang JC, Hou L, Cao PR, Wu L, Zhang QS, Yang HY, Zang Y*, Ding JP*, Li J*. Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases. Sci Rep. 2015 May 11;5:10115. IF/5-IF: 5.228/5.525    cited: 2 

11. Deng SS#, Zhang C#, Wang H, Zang Y*, Li J, He XP*, Chen GR. Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage. Carbohydr Res. 2015 May 18;408:114-8. IF/5-IF: 1.817/2.023    cited:1 

12. Deng SS#, Wu LY#, Wang YC, Cao PR, Xu L, Li QR, Liu M, Zhang L, Jiang YJ, Yang XY, Sun SN, Tan MJ, Qian M, Zang Y*, Feng L*, Li J*. Protein kinase A rescues Microtubule affinity-regulating kinase 2-induced microtubule instability and neurite disruption by phosphorylating Serine 409. J Biol Chem. 2015 Jan 30;290(5):3149-60 IF/5-IF: 4.258/4.403 cited:0 

13. Li KB#, Zang Y#, Wang H, Li J*, Chen GR, James TD, He XP*, Tian H.Hepatoma-selective imaging of heavy metal ions using a 'clicked' galactosyl rhodamine probe. Chem Commun (Camb). 2014, 50:11735-7  IF/5-IF: 6.567/6.628 cited: 5 

14. Cheng CY#, Feng YY, Zang Y*, Li J, He XP*, Chen GR, Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells. Carbohydr Res 2014, 394:39-42  IF/5-IF: 1.817/2.023 cited: 1 

15. He XP#, Deng Q, Cai L, Wang CZ, Zang Y*, Li J*, Chen GR*, Tian H. Fluorogenic resveratrol-confined graphene oxide for economic and rapid detection of Alzheimer's disease. ACS Appl Mater Interfaces. 2014, 6:5379-82. IF/5-IF: 7.145/7.332 cited: 25 

16. Li KB#, Wei XL, Zang Y*, He XP*, Chen GR, Li J* and Chen KX. Revisit of a dipropargyl rhodamine probe reveals it alternative ion sensitivity in both a solution and live cells. Analyst 2013 Dec 7;138(23):7087-9  IF/5-IF: 4.033/4.092 cited: 7 

17. Zhang HL#, Wei XL, Zang Y, Cao JY, Liu S, He XP*, Chen Q, Long YT, Li J*, Chen GR*, Chen K. Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite. Adv Mater. 2013, 25:4097-101. IF/5-IF: 18.96/18.862 cited: 48